Commiphora myrrha inhibits itch‑associated histamine and IL‑31 production in stimulated mast cells
نویسندگان
چکیده
منابع مشابه
Gallic acid inhibits histamine release and pro-inflammatory cytokine production in mast cells.
The discovery of drugs for the treatment of inflammatory allergic diseases such as, asthma, allergic rhinitis, and sinusitis is a very important subject in human health. Gallic acid (3,4,5-trihydroxybenzoic acid), a polyphenyl natural products from gallnut and green tea, is known to have anti-oxidant, anti-inflammatory, anti-microbial, and radical scavenging activities. The aim of the present s...
متن کاملAzelastine and '5Ca uptake Antiallergic agent, azelastine, inhibits 45Ca uptake and histamine release in rat mast cells stimulated by antigen
The effect of antiallergic agent, azelastine, was examined in immunogical secretory process of mast cells. 1. Azelastine significantly inhibited '"Ca uptake by mast cells stimulated by antigen, and the maximum inhibition was attained at a concentration of 50 11 11/me showing approximately 30.5 % inhibition. 2. Azelastine also inhibite the release of histamine from mast cells by antigen. The max...
متن کاملCytotoxicity activity of extracts and compounds from Commiphora myrrha resin against human gynecologic cancer cells
The purpose of this report is to explore the cytotoxicity effects of extracts and compounds from Commiphora myrrha resin on human gynecologic cancer cells. The results showed that AE (85% EtOH extract), and petroleum ether extract (PE) from C. myrrha significantly inhibited cell proliferation of A2780, SK-OV-3, and Shikawa with dose-dependent relation in vitro. The inhibitory effects of AE and ...
متن کاملMast cells and histamine contribute to bile acid-stimulated secretion in the mouse colon.
Certain dihydroxy bile acids cause secretory diarrhea when present in the colonic lumen at inappropriately high concentrations. However, the mechanism underlying the secretagogue activity has not been fully elucidated. Experiments were performed to test whether mast cells and one of their major mediators, histamine, might contribute to the secretory effect. Chenodeoxycholic acid, a secretory bi...
متن کاملHistamine, Mast Cells, and Heart Failure
e have known about histamine receptors in the heart for any years (1). The human H1and H2-histamine recepors were cloned and characterized in the early 1990s (2,3), ollowed closely by the human H3and H4-histamine eceptors several years later (4,5). Histamine is a natural ody constituent that is found throughout the body, espeially the central nervous system, mast cells, gastric mucosa arietal c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Experimental and Therapeutic Medicine
سال: 2019
ISSN: 1792-0981,1792-1015
DOI: 10.3892/etm.2019.7721